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Natural Products Innovation

Natural Products Innovation

Natural Products Innovation

We are primarily focused on the improvement and optimization of natural products as therapeutic options for patients with chronic disorders who do not respond well to traditional pharmaceuticals.

Traditional Medicine

Natural Products Innovation

Natural Products Innovation

Traditional medicine has been undervalued and  we aim to explore the safety and efficacy of novel secondary metabolites present in traditional methods, including complex herbal extractions produced in both formulations for oral administration and smoking.

Eco-Friendly Processes

Natural Products Innovation

Eco-Friendly Processes

Our team wants to develop the most eco-friendly and efficient means for producing these products without the use of toxic chemicals or the creation of unnecessary byproducts.

Cannabis Smoke Extract

 A New Innovation in the Hemp/CBD and Medical/Adult-Use Cannabis Industries


Real Isolates has developed a commercially viable method to harvest cannabinoids and terpenes from cannabis smoke.  Smokenol™ cannabis smoke extract is rich in common and rare cannabinoids and enables a new category of oral, topical, and inhaled cannabis products.


Our patented extraction method provides  effects  similar to those from smoking. This is an important innovation because over 75% of medical cannabis patients report they find smoking cannabis more effective than using conventional edibles.


Products containing Smokenol™ cannabis smoke extract will feel different because of the unique diversity and balance of cannabinoids. Conventional edibles are made from cannabinoids extracted from the ‘raw’ plant which are then heated at the lowest temperature necessary to ‘activate’ (decarboxylate) while still preserving the THC and CBD. These extracts usually consist predominantly of THC or CBD but do not contain the richer diversity and balance of cannabinoids created by the high heat necessary to make cannabis smoke.

Learn About Smokenol
Profound Naturals Hemp Smoke Extract - CBD tinctures and topicals

SMOKENOL MADE FROM HEMP

March 28, 2022 - Real Isolates has formed a subsidiary named Smokenol Day™ to manufacture and sell hemp-derived Smokenol™ products containing low to no detectable levels of THC. 


These products are available on-line and at retail stores under the brand Profound Naturals™.  For wholesale inquiries for Profound Naturals™ hemp-derived products please visit ProfoundNaturals.com.



Medical and Adult-Use


The Real Isolates companies do not manufacture medical or adult-use cannabis products but do license the patented Smokenol™ extraction method to other companies.  Contact sales@Realisolates.com to discuss licensing for your company.

Learn More About Profound Naturals

Smoke n' Science Podcast

Approachable, casual conversations about how Cannabis and other natural products interact with your body. Real Isolates and Smokenol sponsor a  podcast to discuss all the nitty gritty details of Cannabis science. The podcast has guests from all aspects of Cannabis such as patients, physicians, and even some celebrities! Our goal is to bridge the gap between the complex science of Cannabis and everyday users. Find us on Apple, Spotify or your favorite streaming service. 

Smoke N' Science

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