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    • Real Isolates - Smokenol
    • Smokenol
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    • Contact
  • Real Isolates - Smokenol
  • Smokenol
  • Find Smokenol Products
  • About Real Isolates
  • Learn
  • Contact

Cannabis Smoke Extract

 A New Innovation in the Hemp/CBD and Medical/Adult-Use Cannabis Industries


Real Isolates has developed a commercially viable method to harvest cannabinoids and terpenes from cannabis smoke. This patent-pending extraction method provides edible effects more similar to those from smoking.  Smokenol™ is rich in common and rare cannabinoids and enables a new category of oral, topical, and inhaled cannabis products.


Products containing Smokenol ™ will feel different because of the unique diversity and balance of cannabinoids. Conventional edibles are made from cannabinoids extracted from the ‘raw’ plant which are then heated at the lowest temperature necessary to ‘activate’ (decarboxylate) while still preserving the THC and CBD. These extracts usually consist predominantly of THC or CBD but do not contain the richer diversity and balance of cannabinoids created by the high heat necessary to make cannabis smoke.

Learn About Smokenol
Profound Naturals Hemp Smoke Extract - CBD tinctures and topicals

'CBD' PRODUCTS - SMOKENOL MADE FROM HEMP

March 28, 2022 - Real Isolates has formed a subsidiary named Smokenol Day™ to manufacture and sell hemp-derived Smokenol products containing low to no detectable levels of THC.  These 'CBD' products are available on-line and at retail stores under the brand 'Profound Naturals™'.


For wholesale inquiries for Profound Naturals™ hemp-derived (CBD) products please visit ProfoundNaturals.com.



Medical and Adult-Use


The Real Isolates companies do not manufacture medical or adult-use cannabis products but do license 

the patent-pending Smokenol™ extraction method to other companies.  Contact sales@Realisolates.com to discuss licensing for your company.

Learn More About Profound Naturals

Smoke n' Science Podcast

The scientific research team at Real Isolates, Dr. Miyabe Shields and Dr. Riley Kirk are hosting a podcast! You may have heard them communicating Cannabis facts on their TikTok or Instagram pages but now Real Isolates and Smokenol are sponsoring this podcast to discuss all the nitty gritty details of Cannabis science. The podcast will have guests from all aspects of Cannabis such as patients, physicians, and even some celebrities! Our goal is to bridge the gap between the complex science of Cannabis and everyday users. Find us on Apple, Spotify or your favorite streaming service. 

Smoke N' Science

Forbes.com July 26, 2022

 Meet The Two Radical Scientists Using TikTok To Make Cannabis Education Accessible - FORBES, Jul 26, 2022 


“It would have taken us both over 10 years in academia to teach that many students, and we did it in less than a year.”  

Read the article

July 6, 2022

Our team just published a chapter in the book "Revolutionizing the Potential of Hemp and Its Products in Changing the Global Economy"! Chapter 6 co-authored by Dr. Miyabe Shields and Dr. Riley Kirk summarizes the pharmaceutical applications of Hemp Cannabis.

January 15, 2022

Real Isolates moves into our new lab space at the Cummings Emerging Tech Center Beverly, MA (!)

International Cannabinoid Research Society 2021

 Transformation of phytocannabinoids by heat, isomerization, dehydration, and derivation of cannabinoids present in Cannabis sativa smoke 


By Real Isolates founders Andrew Westerkamp and Miyabe Shields and presented by Real Isolates Chief Scientist Dr. Miyabe Shield.


 ... "Most notably, the CBD isolate which was > 98% pure transformed into 18 separate peaks. 

Watch Presentation

October 10, 2021

Dr. Miyabe Shields, Chief Scientific Officer (CSO) at Real Isolates recently gave a talk at Cannabis Grand Rounds presented by Pivital Edu. Dr. Shields discussed how the endocannabinoid system is involved in the regulation and dysregulation of mental health. These matters are particularly pressing following the COVID19 pandemic, as we’ve seen substantial increases in the diagnosis of anxiety and depressive disorders. 

Smokenol - We smoked it for you - Extracts from cannabis smoke

May 5, 2021 Real Isolates launches Smokenol.com Website

Real Isolates has developed a commercially viable pyrolytic extraction method to harvest cannabinoids and terpenes from cannabis smoke.  These patent-pending formulations are rich in common and rare cannabinoids (including pyrocannabinoids and pyroterpenes) and enable a new category of oral, topical, and inhaled cannabis therapies. 


Smokenol™ products are made under license from Real Isolates, LLC.  Consumers and product manufacturers may learn more on the Smokenol.com site.  For inquiries about IP licensing please contact Sales@Realisolates.com

Smokenol Sessions - free cannabis education

May 5, 2021 Real Isolates Launches Free Cannabis Education

Smokenol Sessions is a free cannabis education video resource with content for all backgrounds and abilities about cannabis and the endocannabinoid system.


Videos will range from beginner (no scientific background) to advanced (masters and/or PhD level content) and are created under the direction of Dr. Miyabe Shields, PhD, Chief Scientific Officer of Real Isolates LLC, co-inventor of Smokenol™, endocannabinoid system pharmacology expert, and cannabis patient.

April 7, 2021

Dr. Miyabe Shields, PHD has their PhD in pharmaceutical sciences and specializes in cannabinoid and endocannabinoid pharmacology.  They will present at the American Chemical Society 2021 Conference in the section “Cannabis Derived Treatments for Specific Medical Conditions: Macromolecular Interactions and Justifications.”  Dr. Shields will be discussing the therapeutic mechanisms of cannabis for mental health disorders. 

January 20, 2021

Real Isolates LLC files PCT and US Patent application for our novel extraction method of plant and fungus material and novel chemical formulation of cannabinoids.


The PCT application allows Real Isolates to seek protection in most countries in the world. The PCT application and non-provisional US patent application, if granted, have the potential to give 20 years of patent protection for both the method and chemical formulation. 

Smokenol enables a new category of hemp and cannabis products

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